Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C–H activation

Palladium(II)-catalyzed direct alkenylation of dihydropyranones.

A palladium(II)-catalyzed direct alkenylation reaction of dihydropyranones was developed. Various substituted dihydropyranones could afford the desired products in reasonable yields. And different acrylates were found to be good coupling partners in this coupling reaction. A Pd(0)/Pd(II) catalytic pathway was proposed to be involved in this coupling reaction.

Palladium-Catalyzed Alkenylation by the Negishi Coupling

Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.

Palladium-catalyzed direct C-3 oxidative alkenylation of phosphachromones.

A method for the synthesis of C-3 alkenylated phosphachromones was developed using a direct intermolecular C-3 alkenylation with activated and non-activated alkenes through C-H activation under aerobic conditions.

Synthesis of 2-Cyclopentenone Derivatives via Palladium-Catalyzed Intramolecular Carbonyl α-Alkenylation.

2-Cyclopentenone derivatives have been efficiently synthesized from 5-bromo-5-hexen-2-ones via palladium-catalyzed intramolecular carbonyl α-alkenylation followed by double-bond migration under mild reaction conditions.